Multiple crystal forms of active molecules, challenge or threat?
Know how to address this question. The understanding of the factors responsible for crystal stability and of the differences in preparation, crystallization conditions, separation, characterization and properties (solubility, dissolution rate, hygroscopicity, chemical stability, but also processability, filterability, particle size distribution, etc.) requires a profound knowledge of solid-state chemistry and crystallography. It is also paramount to […]
The structure–property relationship of four crystal forms of rifaximin
Dario Braga, Fabrizia Grepioni, Laura Chelazzi, Manuela Campana, Donatella Confortini and Giuseppe C. ViscomiReceived 8th June 2012, Accepted 3rd August 2012DOI: 10.1039/c2ce25920f The crystal structures of four crystal forms of rifaximin, named alpha, beta, delta and epsylon have been elucidated by a combination of single crystal and powder diffraction experiments with synchrotron and X-ray sources. […]
PolyCrystalLine nascita di una impresa
Polycrystalline s.p.a. (PCL) nasce nel 2005 come spinoff del gruppo di Molecular Crystal Engineering dell’Università di Bologna. PolyCrystalLine (PCL) è un esempio di trasferimento di conoscenze dal mondo accademico al mondo industriale. Iniziamo con un breve cenno storico. Alla fine degli anni 90, un paio di eventi scientifici scuotono il mondo dell’industria farmaceutica. In primo […]